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pentobarbital will lower the extent or impact of guanfacine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Sturdy or average CYP3A4 inducers considerably lessen guanfacine plasma concentrations and elimination 50 %-lifestyle.pentobarbital will lessen the extent or effect of theophylline by impacti